PROBLEM TO BE SOLVED: To provide a novel and useful adenosine triphosphatase (ATPase) expression inducer, and to provide a cosmetic composition with an ATPase expression inductive action.SOLUTION: The invention provides an ATPase expression inducer containing a phenylethylamine derivative or synephrine. The invention also provides a cosmetic composition (skin and hair cosmetics) for preventing reduction of a dermal barrier function, hypoactivity of skin epidermis, skin wrinkle formation, reduction of skin tension and gloss, rough and dry skin, and the like by being deeply involved in skin constancy through an adenosine triphosphatase expression inductive action of the phenylethylamine derivative or synephrine.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】新規で有用であり、アデノシン三リン酸フォスファターゼ(ATPase)発現誘導剤、更に、ATPase発現誘導作用による化粧料組成物の提供。【解決手段】フェニルエチルアミン誘導体又はシネフリンを含有するATPase発現誘導剤。フェニルエチルアミン誘導体又はシネフリンのアデノシン三リン酸フォスファターゼ発現誘導作用により、皮膚の恒常性に深く関与して、皮膚のバリア機能の減少、皮膚表皮の機能低下、皮膚のシワ形成、皮膚の張りやツヤの減少、皮膚の肌荒れ等を防ぐ化粧料組成物(皮膚&毛髪化粧料)。【選択図】なし