GOAD MARY ELIZABETH PECQUET,HASKELL MELISSA M,SCHRIER DENIS,WOOD SUSAN A
申请号：
IN3273/KOLNP/2011
公开号：
IN2011KN03273A
申请日:
2011.08.03
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally- soluble bioactive agents such as, but not limited to, proteins of the TGF-β superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is BMP-7. The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the peripheral site of intravenous administration of the bioactive agent.
