HSU, ERIC, C.,FLEET, CARLOS,CHEUNG, ANTHONY,GAO, JUN
申请号：
EP08833604
公开号：
EP2195035A4
申请日:
2008.09.26
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provided are methods for altering the diameter of chitosan-nucleic acid polyplexes.
