CHEUNG, ANTHONY,FLEET, CARLOS,GAO, JUN,HSU, ERIC C.
申请号：
CA2700842
公开号：
CA2700842C
申请日:
2008.09.26
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention provides highly concentrated chitosan-nucleic acid polyplexcompositions and dispersions, and methodsfor producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixingof chitosan solution and nucleic acid solution, followed by furtherconcentrating the dispersion of chitosan-nucleic acid polyplexes,optionally with an aggregation inhibitor. Further provided are methods foraltering the diameter of chitosan-nucleic acid polyplexes.
