The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones to processes for their preparation the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia postpartum hemorrhage hemorrhagic shock trauma surgery transplantation stroke liver diseases hereditary angioedema nosebleed and synovitis and cartilage damage following hemarthrosis.
