Gosudarstvennoe byudzhetnoe uchrezhdenie zdravookhraneniya goroda Moskvy Nauchno-issledovatelskij institut skoroj pomoshchi imeni N.V. Sklifosovskogo Departamenta zdravookhraneniya g. Moskvy
发明人:
Krylov Vladimir Viktorovich,Крылов Владимир Викторович,Tokarev Aleksej Sergeevich,Токарев Алексей Сергеевич,Evdokimova Olga Liverevna,Евдокимова Ольга Ливерьевна,Rak Vyacheslav Avgustovich,Рак Вячесла
申请号：
RU2017120837
公开号：
RU0002655880C1
申请日:
2017.06.14
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely, to medical radiology. Method for planning the radiosurgical treatment of brain tumors located in the region of the motor cortex and/or adjacent to this region, includes: conducting the MRI of brain without contrast medium to obtain a series of anatomical sections images of the brain, time-weighted T1. Conducting fMRI studies to obtain a series of functional images of the motor zones of the cerebral cortex, conducting nTMS motor zones of the cerebral cortex with obtaining of appropriate images. Verify the location of the tumor relative to the motor zones and its shape which is close to the sphere or ellipsoid of rotation by the images obtained. Install the stereotaxic coordinating frame. Record MRI in the T1 sequence using a contrast agent with a localization device, obtaining an anatomical image of the brain with confidence marks designed to determine the target coordinates. Import the obtained images of MRI, fMRI, nTMS into the treatment planning program file for stereotactic radiosurgery, scale and combine them on the basis of a single system of stereotaxic coordinates to obtain a single series of images with a number of voxels, characterizing the location of the motor zones of the cerebral cortex and tumors obtained as a result of MRI, fMRI and nTMS, with the subsequent obtaining of the image of the final zone of the motor cortex at the intersection of the regions obtained with fMRI and nTMS. Contour the tumor and the final motor zone at each cut, obtaining a three-dimensional image of the motor zone, then plan the treatment of the tumor, taking into account the mutual location of the tumor and the motor zone. In this case, prescribe the prescribed dose (PD) and the prescribed isodose (PI), select the isocycles with the collimator size of 4 mm and/or 8 mm and/or 16 mm, fill the tumor volume using first larger isocenters, then the smaller ones, with guarantee of conformal filling of the entire volum
