THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;ADVAXIS, INC.; INC.;ADVAXIS
发明人:
WALLECHA, ANU,PATERSON, YVONNE
申请号：
CA2998857
公开号：
CA2998857A1
申请日:
2016.09.13
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention discloses a process for manufacturing a formulation comprising a drug substance, said drug substance comprising a recombinant Listeria comprising a human papilloma virus (HPV) antigen fused to a Listeriolysin O (LLO) protein fragment. The invention further discloses methods of using treating, protecting against, and inducing an immune response against cervical cancer comprising administration of the recombinant Listeria strain. The present invention also provides methods for inducing an anti-E7 CTL response in a human subject and treating HPV-mediated diseases, disorders, and symptoms, comprising administration of the recombinant Listeria strain.
