The Trustees of the University of Pennsylvania;Advaxis, Inc.
发明人:
Yvonne PATERSON,John Rothman
申请号：
US14579819
公开号：
US20150343047A1
申请日:
2014.12.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides methods of treating, protecting against, and inducing an immune response against cervical dysplasia and cancer, comprising the step of administering to a subject a recombinant Listeria strain, comprising a fusion peptide that comprises an LLO fragment and an E7 and/or E6 antigen. The present invention also provides methods for inducing an anti-E7 CTL response in a human subject and treating HPV-mediated diseases, disorders, and symptoms, comprising administration of the recombinant Listeria strain.
