The disclosure is directed to an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against B-cell maturation antigen (BCMA) conjugated to a cytotoxin. The disclosure also provides compositions comprising the antibody-drug conjugate and methods of killing multiple myeloma cells (including multiple myeloma stems cells) that express BCMA by contacting multiple myeloma cells with the ADC.本發明係關於一種抗體-藥物結合物(ADC)，其包含針對與細胞毒素結合之B細胞成熟抗原(BCMA)之單株抗體或其抗原結合片段。本發明亦提供包含該抗體-藥物結合物之組合物，及藉由使多發性骨髓瘤細胞與該ADC接觸來殺滅表現BCMA之多發性骨髓瘤細胞(包括多發性骨髓瘤幹細胞)的方法。
