Laurence Tatiana Rimsky,Inky Paul Madeleine De Baere,Bart Anna Julien Maes,Marie-Pierre T. M. M. G. De Bethune,Guenter Kraus,Elisa Mokany,Alison Velyian Todd
申请号：
US12094708
公开号：
US08673551B2
申请日:
2006.12.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to methods and means for the evaluation of HIV replicative capacity in a given environment. In particular, the invention provides a growth competition assay that can determine relative viral fitness using a recombinant tagged HIV-1 virus system. The methods rely on plasmid vectors, amplicons, primers and probes, and the generation of replication-competent viruses therefrom. Said methods and materials may find use in multiple fields including diagnostics, drug screening, pharmacogenetics and drug development.
