KIM Do Hee,Shin Seul Gi,Lim Sung Su,Pae Ae Nim,Kim Dong Jin,Kim Yun Kyung
申请号：
US201715709822
公开号：
US2018119169(A1)
申请日:
2017.09.20
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
Disclosed is a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.
