Boerries Brandenburg,Ronald Vogels,Joost A. Kolkman,Robert Heinz Edward Friesen
申请号：
US16455151
公开号：
US10703804B2
申请日:
2019.06.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said strains comprising HA of two different HA subtypes from phylogenetic group 2； or capable of specifically binding to hemagglutinin (HA) of at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2； or capable of specifically binding to hemagglutinin (HA) of at least one influenza B virus strain are provided. The binding molecules preferably are also capable of neutralizing at least two influenza A virus strains from phylogenetic group 2； or capable of neutralizing at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2； or capable of specifically neutralizing at least one influenza B virus strain.
