MITKIN, OLEG DMITRIEVICH,KADIEVA, MADINA GEORGIEVNA,IVACHTCHENKO, ALEXANDRE VASILIEVICH
申请号：
CA2845524
公开号：
CA2845524A1
申请日:
2011.12.13
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention relates to novel substituted methyl amines, serotonin 5-HT6 receptor antagonists, active ingredients, pharmaceutical compositions and a method for preventing and treating diseases of the central nervous system, as well as to molecular instruments, wherein the novel substituted methyl amines are compounds of general formula 1 and crystalline forms, polycrystalline forms, pharmaceutically acceptable salts and/or hydrates thereof, where: W is naphthalene, indolizine or quinoline； R1 is hydrogen, fluorine, chlorine, methyl； R2 is hydrogen, fluorine, methyl, phenyl, thiophen-2-yl, furan-2-yl, pyridyl, piperazin-1-yl or 4-methylpiperazin-1-yl； R3 is methyl； or W is benzene, R3 has the above meaning； R1 is 3-C 1, R2 is ?-piperazin-1-yl or 3-(4-methylpiperazin-1-yl)； or R1 is hydrogen, R2 is phenyl or pyridyl； or R1 is hydrogen, fluorine, chlorine, methyl； R2 is 4-piperazin-1-yl or 4-(4-methylpiperazin-1-yl)； or W is oxazole, R3 is optionally substituted methyl； R1 is chlorine or fluorine, R2 is methyl, or R1 is hydrogen, fluorine, chlorine, methyl； R2 is piperazin-1-yl, 4-methylpiperazin-1-yl, or R1 is chlorine, fluorine or methyl； R2 is furan-2-yl, or R1 is hydrogen, fluorine, chlorine, methyl； R2 is furan-2-yl, R3 is (tetrahydrofuran-2-yl)methyl, or R1 is hydrogen, fluorine, chlorine, methyl； R2 is thiophen-2-yl, R3 is 2-methoxyethyl, or R1 is chlorine or fluorine, R2 is thiophen-2-yl, R3 is methyl.
