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PHENYLPYRAZOL DERIVATIVES
专利权人:
LTD.;TAJSO FARMAS'JUTIKAL KO.;TAJSO FARMASJUTIKAL KO.
发明人:
NAKAMURA Tosio (JP),НАКАМУРА Тосио (JP),TATsUZUKI Makoto (JP),ТАЦУЗУКИ Макото (JP),NOZAVA Dai (JP),НОЗАВА Даи (JP),TAMITA Tomoko (JP),ТАМИТА Томоко (JP),MASUDA Sejdzi (JP),МАСУДА Сейдзи (JP),OKhTA Khi,NAKAMURA TOSIO,НАКАМУРА Тосио,TATSUZUKI MAKOTO,ТАЦУЗУКИ Макото,NOZAVA DAI,НОЗАВА Даи,TAMITA TOMOKO,ТАМИТА Томоко,MASUDA SEJDZI,МАСУДА Сейдзи,OKHTA KHIROSI,ОХТА Хироси,KASIVA SUKHEI,КАСИВА Сухеи,FUDZIN
申请号:
RU2010123924/04
公开号:
RU0002480456C2
申请日:
2008.11.13
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a phenylpyrazol derivative presented by formula (1) or to its pharmaceutically acceptable salt: wherein R1 and R2, which may be identical or different, each represents C1-C6 alkyl, or R1 and R2 are coupled together with an adjacent nitrogen atom to form a 5-6-merous saturated heterocylic ring (wherein the mentioned saturated heterocylic ring may be substituted by halogen or C1-C6 alkyl), n represents an integer 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R has one of formulas (I)-(V), (VII) or (VIII):(wherein Z1 and Z2, which may be identical or different, each represents -CH2-, -O- or -NR11-, p represents an integer 0 to 3, q represents an integer 0 to 1, r and s which may be identical or different, which represents an integer 0 to 2, R3 represents halogen, C1-C6 alkyl, or hydroxy, R4 and R5 which may be identical or different, each represents a hydrogen atom, C1-C6 alkyl (wherein said C1-C6 alkyl may be substituted by hydroxy, hydroxy- C1-C6 alkoxy, C2-C7 alkoxycarbonyl or carboxy), or formula -(CH2)m-Ar1 (wherein Ar1 represents wherein (wherein said phenyl is substituted by halogen or C1-C6 alkyl), and m represents an integer 0 to 1), R6 represents oxo, R7 represents a hydrogen atom or C1-C6 alkyl, R8 represents C1-C6 alkyl (wherein said C1-C6 alkyl may be substituted by halogen), C1-C6 alkoxy (wherein said C1-C6 alkoxy is substituted by halogen) or formula -(CH2)1-Ar2 (wherein Ar2 represents phenyl (wherein said phenyl is substituted by C1-C6 alkoxy, hydroxyl or cyano) or pyridinyl, and 1 represents an integer O to 1), G represents -CO- or -SO2-, R9 represents C1-C6 alkyl, C1-C6 alkoxy, phenyl (wherein said phenyl may be substituted by halogen or pyridinyl, and R11 represents C1-C6 alkyl)}.EFFECT: there are produced new compounds and a preventive or therapeutic agent on the basis of said compounds which can find application in medicine for treating dementia, Alzheimer's disease,
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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