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ISOLATION AND PURIFICATION OF ANTI-IL-13 ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY
专利权人:
ABBOTT LABORATORIES
发明人:
申请号:
IL21889712
公开号:
IL218897D0
申请日:
2012.03.27
申请国别(地区):
IL
年份:
2012
代理人:
摘要:
Disclosed herein are methods for the isolation and purification of anti- IL- 13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., Protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
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中国工程科技知识中心
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