Problem to be solved: to provide an immuno adjuvant composition, and to provide an immunoregulatory substance, such as lipopolysaccharide (LPS) analog, which is reduced in toxicity and its use.The immune response regulating substance of the present invention is excellent in safety because it is excellent in immune immunity inducing ability for endogenous immunity and a specific disease source substance, and does not only exhibit the immunity enhancing effect, but is hardly toxic.Also, the vaccine containing immune response modulators of the present invention enhances both immune response modulators and alum (alum) to increase the immune enhancing efficacy as compared with the case where the immune response regulator is used alone.Diagram【課題】 免疫補助剤組成物を提供し、特に、毒性を減少させたリポポリサッカライド（ｌｉｐｏｐｏｌｙｓａｃｃｈａｒｉｄｅ；ＬＰＳ）類似体である免疫反応調節物質及びその用途を提供する。【解決手段】本発明の免疫反応調節物質は、内在性免疫及び特定病源体に対する適応免疫反応誘導能に優れ、免疫増強効能を発揮するだけでなく、毒性がほとんどないため安全性に非常に優れている。また、本発明の免疫反応調節物質を含むワクチンは、免疫反応調節物質とミョウバン（ａｌｕｍ）の両方を含むことによって、免疫反応調節物質を単独で使用する場合に比べて向上した免疫増強効能を発揮する。【選択図】 図２
