ARIEL FUENTES,HUGO SOVINO,LEON TREJO,LUIGI DEVOTO,PABLO CÉSPEDES,RICARDO POMER
申请号：
BRPI0812578
公开号：
BRPI0812578A2
申请日:
2008.06.04
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
Pharmaceutical compositions appropriate for the vaginal administration of steroids are described, to be used in a hormone replacement therapy, during menopause and to support the luteal phase of in vitro fertilization cycles. Compositions are characterized by the incorporation of polymers and disintegrators combinations, that allow an adequate mucous adherence and bio-availability of steroid hormones in the endometrium. This administration method reduces the systemic levels of steroids, allows a longer term in between doses, thus reducing side effects, and it prevents residues gathering inside the vaginal cavity.
