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NOUVEAUX REACTIFS DE RETICULATION, NOUVELLES MACROMOLECULES, NOUVEAUX CONJUGUES THERAPEUTIQUES, ET PROCEDES DE SYNTHESE ASSOCIES
专利权人:
LLC;CELLMOSAIC
发明人:
HUANG, YUMEI
申请号:
CA2841313
公开号:
CA2841313A1
申请日:
2012.07.18
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<;1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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