您的位置: 首页 > 农业专利 > 详情页

AGENT THÉRAPEUTIQUE POUR LES CARDIOMYOPATHIES, L'INFARCTUS DU MYOCARDE ANCIEN ET L'INSUFFISANCE CARDIAQUE CHRONIQUE
专利权人:
Osaka University;StemRIM Inc.
发明人:
申请号:
EP18745136.4
公开号:
EP3556378A1
申请日:
2018.01.26
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present inventors have found that HMGB 1 fragment peptides having a particular amino acid sequence exhibit the effects of improvement of cardiac function, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of dilated cardiomyopathy, that the particular HMGB 1 fragment peptides also exhibit the effects of improvement of cardiac function, inhibition of cardiomegaly, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of ischemic cardiomyopathy caused by old myocardial infarction, and that the particular HMGB 1 fragment peptides exhibit the effects of inhibition of cardiomyocyte hypertrophy and inhibition of myocardial fibrosis in an animal model of hypertensive cardiomyopathy. Based on these findings, pharmaceutical compositions are provided for the prevention and/or treatment of cardiomyopathy and old myocardial infarction and chronic heart failure resulting therefrom, which comprise an HMGB 1 fragment peptide having a particular amino acid sequence.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充