Wayne State University;Duquesne University of The Holy Spirit
发明人:
申请号：
EP18851925.0
公开号：
EP3675864A1
申请日:
2018.08.30
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Pyrrolopyrimidine compounds and pharmaceutically acceptable salt thereof are provided. Pharmaceutical compositions having these compounds and acceptable pharmaceutical carriers are disclosed. Pyrrolopyrimidine compounds and pharmaceutically acceptable salts are set forth that are useful to treat a patient having pancreatic, colon, and lung cancers, to target mitochondrial metabolism, and to target serine hydroxymethyltransferase 2 (SHMT2) and 5,10-methylene tetrahydrofolate dehydrogenase 2 (MTHFD2).
