ASCLEPIX THERAPEUTICS, INC.;THE JOHNS HOPKINS UNIVERSITY
发明人:
GREEN, JORDAN J.,PANDEY, NIRANJAN,POPEL, ALEKSANDER S.,CAMPOCHIARO, PETER A.,KIM, JAYOUNG,LIMA E. SILVA, RAQUEL,SHMUELI, RON,MIRANDO, ADAM
申请号：
CA3063140
公开号：
CA3063140A1
申请日:
2018.05.08
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides microparticle compositions comprising antiangiogenic peptides, as well as methods of treatment, including for macular degeneration. In various aspects and embodiments, the present invention provides microparticle compositions providing extended release of anti-angiogenic peptides. The microparticle of the present invention comprises poly(lactide-co-glycolide) (PLGA) having a having lactic acid (LA) to glycolic acid (GA) ratio (LVG) of more than 1:1； the microparticle further comprises, e.g., encapsulates, an anti-angiogenic peptide derived from the a5 fibril of type IV collagen.
