Asclepix Therapeutics, Inc.;The Johns Hopkins University
发明人:
Green, Jordan J.,Pandey, Niranjan,Popel, Aleksander S.,Campochiaro, Peter A.,Kim, Jayoung,Lima E. Silva, Raquel,Shmueli, Ron,Mirando, Adam
申请号：
AU2018266690
公开号：
AU2018266690A1
申请日:
2018.05.08
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The present invention provides microparticle compositions comprising antiangiogenic peptides, as well as methods of treatment, including for macular degeneration. In various aspects and embodiments, the present invention provides microparticle compositions providing extended release of anti-angiogenic peptides. The microparticle of the present invention comprises poly(lactide-co-glycolide) (PLGA) having a having lactic acid (LA) to glycolic acid (GA) ratio (LVG) of more than 1:1； the microparticle further comprises, e.g., encapsulates, an anti-angiogenic peptide derived from the α5 fibril of type IV collagen.
