A medicine patch of the present invention comprises: a medicine part to be directly attached to a lesion or a needed part of a human body by attaching a transdermal medicine and a wrapping paper part for surrounding and sealing the outside of the medicine part and preventing the medicine from leaking into the outside when the medicine leaks. The medicine part includes: a medicine layer including a transdermal medicine and a protective film which is attached to an upper portion of the medicine to prevent loss of the medicine and maintain flexibility on the lesion and a release film layer which is attached to a lower portion of the medicine layer, prevents the medicine layer from coming into direct contact with the wrapping paper or being contaminated by foreign materials, prevents the medicine part from being taken out from the wrapping paper part with difficulty due to adhesion between the medicine part and the wrapping paper part, and is removed when being attached on the lesion. Four sides of the release film layer are longer than those of the medicine layer by a predetermined length. The edge of four sides of the release film layer has anti-attachment protrusions which prevent the medicine part from being taken out from the wrapping paper part with difficulty due to adhesion between the medicine part and the wrapping paper part since the wrapping paper part is smeared with the medicine due to a leakage of the medicine by the weight of the medicine patch when the medicine patches are arranged in layers or as a predetermined period of time elapses. The anti-attachment protrusions are formed higher than the thickness of the medicine layer. According to the medicine patch and a method for manufacturing the same, the anti-attachment protrusions are formed on the release film layer to prevent the medicine from being smeared on the wrapping paper, thereby minimizing a failure rate in use. In addition, the medicine yield is increased from 60 to 80% through a manufacturin
