Cyclized peptides derived from the hyaluronan binding region of RHAMM are provided. Pharmaceutical compositions and methods for using the peptides and pharmaceutical compositions are also provided. The peptides and pharmaceutical compositions can be used for the treatment of cancer, inflammatory disorders, autoimmune disorders, and fibrotic disorders.L'invention concerne des peptides cyclisés dérivés de la région de liaison au hyaluronane de RHAMM. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation de ces peptides et de ces compositions pharmaceutiques.