COLVIN, ARTHUR E.,DALE, GREGORY A.,ZERWEKH, PAUL SAMUEL,LESHO, JEFFREY C.,LYNN, ROBERT W.
申请号：
CA2340005
公开号：
CA2340005C
申请日:
1999.08.26
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
An optical-based sensor (10) for detecting the presence or amount of ananalyte using both indicator and reference channels. The sensor has a sensorbody (12) with a source of radiation embedded therein (18). Radiation emittedby the source interacts with indicator membrane (3) indicator molecules (16)proximate the surface of the body. At least one optical characteristic ofthese indicator molecules varies with analyte concentration. For example, thelevel of fluorescence of fluorescent indicator molecules or the amount oflight absorbed by light-absorbing indicator molecules can vary as a functionof analyte concentration. In addition, radiation emitted by the source alsointeracts with reference membrane indicator molecules proximate the surface ofthe body. Radiation (e.g., light) emitted or reflected by these indicatormolecules enters and is internally reflected in the sensor body.Photosensitive elements within the sensor body generate both indicator channeland reference channel signals to provide an accurate indication of theconcentration of the analyte. Preferred embodiments are totally self-containedand are sized and shaped for use in vivo in a human being. Such embodimentspreferably include a power source, e.g. an inductor, which powers the sourceof radiation using external means, as well as a transmitter, e.g. an inductor,to transmit to external pickup means the signal representing the level ofanalyte.
