PROBLEM TO BE SOLVED: To provide a novel crystal of 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene that is useful as an active pharmaceutical ingredient and an intermediate thereof because of its excellent stability.SOLUTION: The crystal is produced by a method including the steps of: agitating 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene semihydrate in a good solvent or a poor solvent agitating the same in water or a mixture of water and a good solvent drying under a condition of reduced pressure under a heating condition and the like.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】安定性に優れているため、医薬品原薬及びその中間体として有用である1-(β-D-グルコピラノシル)-4-メチル-3-[5-(4-フルオロフェニル)-2-チエニルメチル]ベンゼンの新規結晶の提供。【解決手段】1-(β-D-グルコピラノシル)-4-メチル-3-[5-(4-フルオロフェニル)-2-チエニルメチル]ベンゼン半水和物を良溶媒中、又は貧溶媒中、水又は水と良溶媒の混合物中で撹拌する、加温条件下に減圧条件にて乾燥する工程などを含む方法で製造される結晶。【選択図】なし
