The invention relates to a pharmaceutical composition comprising cis-(E)-4-(3-fluorophenyl)-2',3',4',9'-tetrahydro-N,N-dimethyl-2'-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1'[1H]-pyrido[3,4-b]indol]-4-amine. The pharmaceutical composition is suitable for topical administration, especially for intravesical administration in the treatment of bladder pain.本發明係關於一種包含順-(E)-4-(3-氟苯基)-2',3',4',9'-四氫-N,N-二甲基-2'-(1-側氧基-3-苯基-2-丙烯基)-螺[環己烷-1,1'[1H]-吡啶并[3,4-b]吲哚]-4-胺之醫藥組合物。該醫藥組合物適用於局部投藥,尤其適用於膀胱內投藥,用於治療膀胱痛。