The present invention relates to propanenitrile containing (R) ‑3‑cyclopentyl‑3‑ [4‑ (7H‑pyrrolo [2,3‑d] pyrimidine‑4‑yl) ‑1H‑pyrazol‑1‑yl] or Pharmaceutical preparations of pharmaceutically acceptable salts thereof for topical skin application, and use in the treatment of skin disorders.本發明涉及包含(R)‑3‑環戊基‑3‑[4‑(7H‑吡咯並[2,3‑d]嘧啶‑4‑基)‑1H‑吡唑‑1‑基]丙腈或其藥學上可接受的鹽的用於局部皮膚施用的藥物製劑,以及在治療皮膚病症中的用途。