A tablet splitting apparatus includes a guide, a catcher, and a splitting mechanism. The splitting mechanism comprises a pair of blades and a pair of blade shifters. The guide, the catcher, and the splitting mechanism are accommodated in a housing. The housing includes an opening and a support. The support and the guide each include a sliding portion. The guide disposed at the supporting position is slid along the sliding portion of the support so as to be detachable from the supporting position through the opening. The blades and the blade shifters each comprise a sliding portion. The blades and the blade shifters are in a slidable contact with each other at the sliding portions. The blades attached to the respective predetermined positions of the blade shifters are slid along the sliding portions of the blade shifters so as to be detachable from the blade shifters through the opening.
