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Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors
专利权人:
John A. Lowe, III;Stanton F. McHardy
发明人:
Stanton F. McHardy,John A. Lowe, III
申请号:
US12870928
公开号:
US08124639B2
申请日:
2010.08.30
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a series of substituted bicyclic[3.1.0]heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R1-R5 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.
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