KIM, JIN SOOK,김진숙,KIM, JUNG HYUN,김정현,KIM, CHAN SIK,김찬식,KIM, YOUNG SOOK,김영숙,SHON, EUN JIN,손은진,JUNG, DONG HO,정동호,LEE, YUN MI,이윤미,YU, SONG YI,유송이,LEE, IK SOO,이익수,LEE, YOUNG SEOP,이영섭,KIM, OHN SOON,김온순
申请号：
KR1020110114806
公开号：
KR1020130049660A
申请日:
2011.11.04
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A pharmaceutical composition and health functional food containing a Hedera rhombea extract for preventing and treating diabetes complication are provided to suppress aldose reductase activity, and to prevent or treat diabetic ophthalmic diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating diabetes complication contains a Hedera rhombea extract or a fraction thereof as an active ingredient. The extract is prepared from branches, leaves, or roots of Hedera rhombea using water, methanol, ethanol, ethyl acetate, or a mixture thereof. The extract is prepared by room temperature extraction, hot water extraction, enfleurage, reflux extraction, sonication, or steaming. The fraction is prepared by suspending the ethanol extract of Hedera rhombea in water, and fractioning with ethyl acetate. Health functional food for preventing or treating diabetes complication contains the extract or the fraction as an active ingredient. [Reference numerals] (AA) Hedera rhombea extract(HR)； (BB) Ethyl acetate, water； (CC) Ethyl acetate fraction(E)； (DD) Water layer； (EE) Butanol； (FF) Butanol fraction(B)； (GG) Water fraction(W)본 발명은 당뇨합병증 치료제 및 이를 이용한 당뇨합병증 치료 방법에 관한 것으로서, 송악 추출물 또는 이의 분획물이 당뇨합병증 발병의 지표인 알도즈 환원효소의 활성을 억제하고, 당뇨모델 동물실험에서 당뇨성 안과관련 질병이 예방 또는 치료되는 효능이 우수하여, 당뇨합병증 예방 또는 치료제로 유용하게 사용될 수 있다.
