#$%^&*AU2006201459B220120809.pdf#####ABSTRACT Compositions and methods for moulding corneal tissue in a patient for correcting or improving refractive errors in the eye, and in particular, compositions and methods for sequentially softening then hardening the corneal tissue, preferably by manipulation of 5 matrix metalloproteinase activity in the cornea. C:\Documets *nd Setinpn a- SduE"\Tem porey Innt FilC\OLK aEs251292i Afo- 7/4/06