Use of lysosomal acid lipase for treating lysosomal acid lipase deficiency in patients

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专利权人:

SYNAGEVA BIOPHARMA CORP.

发明人:

Quinn, Anthony

申请号：

NZ71501411

公开号：

NZ715014A

申请日:

2011.09.09

申请国别(地区):

NZ

年份:

2018

代理人:

摘要：

Disclosed is an isolated recombinant human lysosomal acid lipase glycoprotein (rhLAL), wherein the rhLAL consists essentially of an N-terminal truncated LAL protein, with N-glycans bonded to the asparagine residues (Asn) that correspond to Asn36 , Asn101, Asn161, Asn273 and Asn321 of SEQ ID NO: 1, with the proviso that the N-glycans do not comprise sialic acid or fucose, and the proviso that the rhLAL does not contain O-glycans, and wherein the N-glycans bonded to the Asn residues that correspond to Asn36 , Asn101, Asn161, Asn273 and Asn321 comprise the glycosylation as specifically defined herein.

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