WILL, DAVID WILLIAM,REID, GEORGE,CHARAPITSA, IRYNA,LEWIS, JOE
申请号：
CA3067080
公开号：
CA3067080A1
申请日:
2018.06.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to benzofuran ureas or carbamates of formula I and heteroaromatic analogues thereof as described below or a tautomer or a pharmaceutically acceptable salt thereof； to a pharmaceutical composition containing these compounds, and to these compounds for use in therapy, especially for use in the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization. Formula (I) wherein X1 is CR1 or N； X2 is CR2 or N； X3 is CR3 or N； X4 is CR4 or N； with the proviso that at most two of X1, X2, X3 and X4 are N； E1 is O or NR6a； E2 is O or NR6b；with the proviso that E1 and E2 are not simultaneously O； L1 is a bond, optionally substituted C1-C6-alkylene or C3-C8-cycloalkylene； L2 is a bond, optionally substituted C1-C6-alkylene, C3-C8-cycloalkylene, etc.； A is 3-, 4-, 5-, 6-, 7- or 8-membered saturated, partially unsaturated or maximally unsaturated carbocyclic ring or a 3-, 4-, 5-, 6-, 7- or 8- membered saturated, partially unsaturated or maximally unsaturated heterocyclic ring； or L2-A forms a group C1-C6-alkylene-OR13, C1-C6--alkylene-SR14 or C1-C6-alkylene-NR15R16； and R1, R2, R3, R4, R5, R6a, R6b, R13, R14, R15 and R16 are as defined in the claims and the description.
