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PROFARMACO GALATTOSILATO DEL KETOROLAC AD USO ANALGESICO E ANTINFIAMMATORIO CON MIGLIORI CARATTERISTICHE FARMACOCINETICHE E PROFILO TOSSICOLOGICO DEL FARMACO DI PARTENZA
专利权人:
RIMOLI; MARIA GRAZIA
发明人:
SASSO, OSCAR,CIRILLO, CARLA,CALIGNANO, ANTONIO,NIEDDU, MARIA,BOATTO, GIANPIERO,DE LUCIA, SALVATORE,CURCIO, ANNALISA,MELISI, DANIELA,RIMOLI, MARIA GRAZIA,ABIGNENTE, ENRICO,CUOMO, ROSARIO,LUONGO, ELVIRA
申请号:
ITNA20080047
公开号:
IT1391812B1
申请日:
2008.07.29
申请国别(地区):
IT
年份:
2012
代理人:
摘要:
Pro-drugs of all non-steroidal anti-inflammatories with free acid function derivatized with an ester group, which have the general structural formula given below (I) where A is: aspirin, diflunisal, benorylate, ibufenac, diclofenac, indomethacin, sulindac, ketorolac, ibuprofen, naproxen, ketoprofen, fenoprofen, flurbiprofen, mefenamic acid, meclof enamic acid, flufenamic acid, niflumic acid, and where in the ester group R can be a sugar (amongst which aldose, or ketose pentose, or esose selected from a group of D- and L-enantioiuers of ribose, glucose, galactose, mannose, arabinose, xilose, allose, altrose, gulose, idose and talose and substituted derivatives thereof, such as glucosamine, galactosamine, N-acetyl glucosamine, N-acetyl galactosamine, N-acetyl ribosamine), a disaccharide, a trisaccharide or an oligosaccharide.
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