Antimicrobial dressings effective for treating biofilms in wounds are provided. One embodiment provides a wound dressing containing a silver-releasing conformable substrate and hydrogel containing a therapeutic substance. The hydrogel layer optionally may contain a pattern and/or one or more apertures, and may be secured by an optional non-adherent netting. A preferred substrate is a silver-coated substrate, for example silver-coated nylon. The silver-coated nylon can be a knitted, woven, compound, or complex fabric. Silver fibers can be combined within non-woven fabrics. The silver containing substrate, can be non-adherent and/or may contain one or more apertures, and/or may contain elastane. The dressing optionally contains one or more of: an adhesive layer, a separation layer, a moisture regulation layer, a film layer, and combinations thereof.
