MEMORIAL SLOAN-KETTERING CANCER CENTER;EUREKA THERAPEUTICS INC.
发明人:
SCHEINBERG DAVID A.,DAO TAO,LIU CHENG,YAN SU
申请号：
NZ61700812
公开号：
NZ617008A
申请日:
2012.04.02
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an isolated antibody, or antigen-binding fragment thereof, comprising: (i) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GGTFSSYAIS, GIIPIFGTANYAQKFQG, and RIPPYYGMDV； and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LCCDR3 respectively, comprising amino acid sequences SGSSSNIGSNYVY, RSNQRPS, and AAWDDSLNGVV； (ii) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GDSVSSNSAAWN, RTYYGSKWYNDYAVSVKS, and GRLGDAFDI； and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC- CDR3 respectively, comprising amino acid sequences RASQSISSYLN, AASSLQS, and QQSYSTPLT； (iii) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GYSFTNFWIS, RVDPGYSYSTYSPSFQG, and VQYSGYYDWFDP； and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC- CDR3 respectively, comprising amino acid sequences selected from SGSSSNIGSNTVN, SNNQRPS, and AAWDDSLNGWV； (iv) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GYNFSNKWIG, IIYPGYSDITYSPSFQG, and HTALAGFDY； and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC- CDR3 respectively, comprising amino acid sequences RASQNINKWLA, KASSLES, and QQYNSYAT； (v) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GFTFDDYGMS, GINWNGGSTGYADSVRG, and ERGYGYHDPHDY； and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC- CDR3 respectively, comprising amino acid sequences GRNNIGSKSVH, DDSDRPS, and QVWDSSSDHVV； or (vi) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GFSVSGTYMG, LLYSGGGTYHPASLQG, and GGAGGGHFDS； and a light chain (LC) variabl
