DECKERT JUTTA,LEJEUNE PASCALE,MAYO MICHELE F,PARK PETER U
申请号：
NZ61205511
公开号：
NZ612055A
申请日:
2011.12.08
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is a pharmaceutical combination comprising an antibody specifically recognising CD38, with the sequence ids as disclosed in the specification, and at least bortezomib, wherein the antibody is capable of killing a CD38+ cell by apoptosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and complement dependent cytoxicity (CDC), and wherein the antibody comprises at least one heavy chain and at least one light chain, wherein (i) the heavy chain comprises three sequential complementarity-determining regions having amino acid sequences represented by SEQ ID NOS: 1, 2, and 3, and wherein the light chain comprises three sequential complementarity-determining regions having amino acid sequences represented by SEQ ID NOS: 4, 5, and 6 (ii) the heavy chain comprises three sequential complementarity-determining regions having amino acid sequences represented by SEQ ID NOS: 7, 8, and 9, and wherein the light chain comprises three sequential complementarity-determining regions having amino acid sequences represented by SEQ ID NOS: 10, 11, and 12 (iii) the heavy chain comprises three sequential complementarity-determining regions having amino acid sequences represented by SEQ ID NOS: 13, 14 (or 81), and 15, and wherein the light chain comprises three sequential complementarity-determining regions having amino acid sequences represented by SEQ ID NOS: 16, 17, and 18 (iv) the heavy chain comprises three sequential complementarity-determining regions having amino acid sequences represented by SEQ ID NOS: 19, 20, and 21, and wherein the light chain comprises three sequential complementarity-determining regions having amino acid sequences represented by SEQ ID NOS: 22, 23, and 24 (v) the heavy chain comprises three sequential complementarity-determining regions having amino acid sequences represented by SEQ ID NOS: 25, 26, and 27, and wherein the light chain comprises three sequential complementarity-determining regions having amino acid sequences represented by SEQ ID
