Douglas Hooper;David Andrews;Thomas Jefferson University
发明人:
Andrews, David W.,Hooper, Douglas C.
申请号：
AU2016246134
公开号：
AU2016246134A1
申请日:
2016.04.11
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the selective reduction of M2 cells by targeting expression of IGF-1R in these cells. The present disclosure further provides methods for treating cancer and enhancing therapeutic by targeting expression of IGF-1R in M2 cells in patients. The pharmaceutical composition of the present invention is effective when administered systemically to subjects in need thereof. The ease of administration of the pharmaceutical composition facilitates treatment and enhances patient compliance.
