[Challenge] In the production method of the patch with oxybutynin hydrochloride as a drug, drugs are contained in the adhesive layer in the supersaturated concentration and dissolution-type, with no harsh conditions of the storage facility, such as after the Great East Japan Earthquake Even a long-term storable and is to provide a method capable of producing at high levels achievable patch both skin permeability and physical properties of the formulation. A A method of manufacturing a patch comprising a support layer and the support layer pressure-sensitive adhesive layer disposed on at least one surface of, And oxybutynin hydrochloride as a drug, the acrylic polymer and / or a rubber polymer as the adhesive base, and liquid paraffin, and sterols, and organic acids, a pressure-sensitive adhesive layer composition containing a tackifier Step A to obtain, A step B of heating 1 to 24 hours at a temperature in the range of the pressure-sensitive adhesive layer composition of 55~70 ℃ of said drug, Upon cooling to room temperature the pressure-sensitive adhesive layer composition after the heating at an average cooling rate of 1~20 ℃ / hour, a step C for obtaining the pressure-sensitive adhesive layer containing the drug in supersaturated concentration and soluble type, Production process of the patch characterized in that it comprises. [Selection Figure] None【課題】 薬物として塩酸オキシブチニンを用いた貼付剤の製造方法において、薬物を過飽和濃度かつ溶解型で粘着剤層中に含有しており、東日本大震災後のような保存設備の無い過酷な条件下であっても長期保存可能、かつ、皮膚透過性及び製剤物性の双方を高水準で達成可能な貼付剤を製造することができる方法を提供すること。【解決手段】 支持体層と前記支持体層の少なくとも一方の面上に配置された粘着剤層とを備える貼付剤の製造方法であって、 薬物としての塩酸オキシブチニンと、粘着基剤としてのアクリル系高分子及び/又はゴム系高分子と、流動パラフィンと、ステロール類と、有機酸類と、粘着付与剤とを含有する粘着剤層組成物を得る工程Aと、 前記粘着剤層組成物を前記薬物の55~70℃の範囲内の温度で1~24時間加熱する工程Bと、 前記加熱後の粘着剤層組成物を1~20℃/時間の平均降温速度で常温まで冷却して、前記薬物を過飽和濃度かつ溶解型で含有する前記粘着剤層を得る工程Cと、を含むことを特徴とする貼付剤の製造方法。【選択図】 なし
