JACOB SWIDORSKI,BRIAN LEE VENABLES,ZHENG LIU,NY SIN,NICHOLAS A. MEANWELL,ALICIA REGUEIRO-REN
申请号：
ARP140100400
公开号：
AR094684A1
申请日:
2014.02.06
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
2. Compounds with pharmacological properties that affect the biological appearance, pharmaceutical ingredients and use methods. In particular, the modified C-19 tributyldiphenyl ether has unique antiviral activity and can be used as a mature drug to inhibit HIV. 1. Characteristic 1: a compound, including an acceptable salt (1) selected from one of the following groups with pharmaceutical characteristics；And a formula compound (2)；X is selected from the phenyl group, heterocyclic, cyclocycloethane c832248331；C₄₋₈ cycloalkenyl,C-cyclocycloalkyl,C-cyclocycloalkenyl,C₄₋₈ oxocycloalkyl,dioxacycloalkyl C₄₋₈,1.Oxacicloalquenilo C832626dioxacycloalkenyl C₆₋₈,C832626 cyclomycinC₆ oxaccyclodialkenyl,C₆₋₉ oxaspirocycloalkyl and C₆₋₉ oxaspirocycloalkenyl；and also where X is substituted with A, where A is at least one member selected from the group of -H, -halo, -hydroxy, -C₁₋₆ alkyl,-alkoxy C₁₋₆,-C833218c-83316262-q1 asphalt,-C₁₋₆-Q¹ alkyl substituted with -alkyl, -CN, -CF₂Q¹,-Nr2,-Coordination and - coordination；There, Q1 from arilo, heterosexual, alternative heterosexual,- yes.-Nr2,-SO₂R⁷,-CONHSO R y -CONHSO NR RHe was chosen from the team-C (O) NR SO R-C (O) NHSO NR R-No. 832222；-I'm 832222-C₃₋₆-COOR² cycloalkyl,-Alquenil c83228331-832626-coordination；-C₂₋₆-COOR² alkynyl,-alkyl C₁₋₆-COOR²,-C₁₋₆ alkyl substituted with -alkyl, -COOR²,CF₂-COOR²,-NHC (O) (CH) -COOR-SO NR C (O) R-Tetrazol y-conhoh, n = 1-6； R1 was selected from the formula group (3)；W absent, or es-ch832222 o-co； Z elected from the list of heads of state No. 831222；-OR³⁰,-Coorrow,-CONR¹⁸R¹⁹,F. Ci, Br, EI； u from constituency 831222；-OR³⁰,-Coorrow,-CONR¹⁸R¹⁹,F, CI, Br, I, aryl and heteroaryl； R² is selected from the group of -H, benzyl, -C₁₋₆ alkyl,C₁₋₆ alkyl substituted with -alkyl and C₁₋₆ alkyl substituted with -aryl； R³ is benzyl, -C₁₋₆ alkyl or C₁₋₆ alkyl substituted with -alkyl； R⁴ is selected from the group of -H, -C₁₋₆ alkyl,-alquil C -C (OR) -cicloalquilo C-Replaced c83218c833331-832626 asphalt-c833183268
