IAN MARK FLETCHER,SIMON CHRISTOPHER BERRY,AGNES CLAUDE MARCELLE PIERRETTE COLOMBANI,DUNCAN CHARLES DICKIE,DARREN JAMES HODSON,ROBERT BERNARD JANSEN,KATHERINE JANE LEE,TIM PAGE,ANDREW JOHN LUDZIK
申请号：
MX2012008906
公开号：
MX2012008906A
申请日:
2011.02.09
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
There is disclosed a process for providing a filled canister (138) for an inhaler (1), in particular a process for supplying a canister (138) and filling the canister (138) with components of a medicament, which canister (138) is suitable for use in a pressurised metered dose inhaler, preferably a breath-actuate inhaler (1). The process comprises providing a canister (138) that is substantially filled with air at ambient conditions and sealing the opening of the canister (138), for example with a metering valve (134). A filling device dispenses a pressurised liquid and/or gas into the sealed, air-filled canister (138) through the metering valve (134). The pressurised liquid and/or gas comprises at least a propellant. The sealed, air-filled canister (138) is substantially devoid of propellant prior to the step of dispensing the pressurised liquid and/or gas. Thereafter the sealed canister (138) is substantially filled with at least some propellant and some air. Preferably the sealed canister (138) also contains a medicament. In the art, pressure-filled canisters are purged with propellant immediately before sealing to remove the air. The present process excludes the purging step and the sealed canisters (138) contain air and no propellant prior when sealed.Se presenta un proceso para proporcionar un cartucho relleno (138) para un inhalador (1), en particular un proceso para suministrar un cartucho (138) y llenar el cartucho (138) con componentes de un medicamento, el cartucho (138) es adecuado para su uso en un inhalador presurizado de dosis controlada, preferentemente un inhalador activado por la inspiración (1) El proceso comprende proporcionar un cartucho (138) que está sustancialmente lleno de aire en condiciones ambientales y sellar la abertura del cartucho (138), por ejemplo, con una válvula dosificadora (134). Un dispositivo de llenado dispensa un líquido y/o gas presurizado al cartucho lleno de aire sellado (138) a través de la válvula dosificadora (134). El
