Berry, Simon Christopher,Colombani, Agnes Claude Marcelle Pierrette,Dickie, Duncan Charles,Fletcher, Ian Mark,Hodson, Darren James,Jansen, Robert Bernard,Lee, Katherine Jane,Ludzik, Andrew John,Page,
申请号：
AU2011214124
公开号：
AU2011214124B2
申请日:
2011.02.09
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
There is disclosed a process for providing a filled canister (138) for an inhaler (1), in particular a process for supplying a canister (138) and filling the canister (138) with components of a medicament, which canister (138) is suitable for use in a pressurised metered dose inhaler, preferably a breath-actuate inhaler (1). The process comprises providing a canister (138) that is substantially filled with air at ambient conditions and sealing the opening of the canister (138), for example with a metering valve (134). A filling device dispenses a pressurised liquid and/or gas into the sealed, air-filled canister (138) through the metering valve (134). The pressurised liquid and/or gas comprises at least a propellant. The sealed, air-filled canister (138) is substantially devoid of propellant prior to the step of dispensing the pressurised liquid and/or gas. Thereafter the sealed canister (138) is substantially filled with at least some propellant and some air. Preferably the sealed canister (138) also contains a medicament. In the art, pressure-filled canisters are purged with propellant immediately before sealing to remove the air. The present process excludes the purging step and the sealed canisters (138) contain air and no propellant prior when sealed.
