HOEKMAN, JOHN D.,SATTERLY, KELSEY H.,DASHEVSKY, INNA,DAS, ADITYA R.,SHREWSBURY, STEPHEN B.
申请号：
CA3087696
公开号：
CA3087696A1
申请日:
2019.01.04
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Methods are provided for treating OFF episodes in a patient with Parkinson's disease or a Parkinson syndrome, comprising administering to a subject with Parkinson's disease or a Parkinson syndrome experiencing an OFF episode an effective dose of a dry pharmaceutical composition comprising L-DOPA, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma levodopa concentration (Cmax) of at least 200 ng/mL, with (b) a mean time to Cmax (Tmax) of levodopa of less than or equal to 60 minutes. Dry pharmaceutical compositions of levodopa suitable for intranasal administration and unit dosage forms comprising the dry pharmaceutical compositions are also provided.
