The present invention relates to the therapeutic use of 4-phenylbutyric acid (4-PB) in the treatment of Alzheimers disease. Particularly, the present invention provides 4-PB at low daily dosis for use in the treatment of Alzheimers disease, pharmaceutical compositions and kits comprising 4-PB at low dosis for the treatment of Alzheimers disease, and methods for treatment of Alzheimers disease involving the administration of 4-PB at low daily dosis.