The present disclosure is related to methods, systems and apparatus for performing electrophysiological measurements utilizing three or more electrodes attached to a patient. The system in various embodiments may include three or more electrodes attached to the patient and at least one analog-to-digital converter with external circuitry electrically coupled to the electrodes. The system may further include a microprocessor for driving the analog-to-digital conversion process, various inputs and variable frequency current outputs electrically coupled to the microprocessor for receiving signals from the electrodes and sending driven current signals to the electrodes.