Matthew David Surman;Alan John Henderson;May Xiaowu Jiang;Alexander Usyatinsky;James Grabowski;Peter Guzzo;Mark Hadden
发明人:
Peter Guzzo,Matthew David Surman,Alan John Henderson,May Xiaowu Jiang,Mark Hadden,James Grabowski,Alexander Usyatinsky
申请号：
US12351561
公开号：
US08716308B2
申请日:
2009.01.09
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I)wherein R1 is H or optionally substituted alkyl； R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN； G is —CR12R13—NR5— or —NR5—CR12R13； R5； is H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R6, —C(═O)—O—R7, or —C(═O)—NR19R20； R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle； R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl； R14 and R15 are each independently H or halogen； L is —CH2—O—, —CH2CH2—, —CH═CH— or a bond； and B is aryl or heteroaryl or cycloalkyl； with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.
