3-1-3-5-1---4--2---6--16---3-- NOVEL POLYMORPHIC FORMS OF -1-3-5-1-METHYL-PIPERIDIN-YLMETHOXY-PYRIMIDIN-2-YL-BENZYL-6-OXO-16-DIHYDRO-PYRIDAZIN-3-YL-BENZONITRILE HYDROCHLORIDE SALT AND PROCESSES OF MANUFACTURING THEREOF
The present invention relates to a process for the preparation of 3- (1- {3- [5- (1 -methyl-piperidin-4-ylmethoxy) -pyrimidin- 2-yl] -benzyl} -6- -Dihydro-pyridazin-3-yl) -benzonitrile and crystalline modifications thereof. The present invention also relates to a method for the preparation of such a crystalline modification and to a method for the production of a pharmaceutical composition which is physiologically and / or physiologically effective in inhibiting, modulating and / or modulating signal transduction of kinases, in particular by inhibition of tyrosine kinases, To the use thereof in the treatment and / or prevention of pathological physiological diseases, for example, pathological physiological diseases such as cancer.본 발명은 하기와 같은 3-(1-{3-[5-(1-메틸-피페리딘-4-일메톡시)-피리미딘-2-일]-벤질}-6-옥소-1,6-디히드로-피리다진-3-일)-벤조니트릴의 히드로클로라이드 용매화물 및 이의 결정질 개질체에 관한 것이다. 본 발명은 또한 이러한 결정질 개질체의 제조 방법, 및 키나아제의 신호 변환의 억제, 조절 및/또는 조정에 의해, 특히 티로신 키나아제의 억제에 의해 야기되고, 매개되고/되거나 증식되는 생리학적 및/또는 병리생리학적 병상, 예를 들어 암과 같은 병리생리학적 병상의 치료 및/또는 예방에서의 이의 용도에 관한 것이다.
