pH Pharma Co., Ltd.;Kimberly Ann TIPTON;Sanjeev SATYAL;Hoyoung HUH;Vasu JAMMALAMADAKA
发明人:
Vasu JAMMALAMADAKA,Kimberly Ann TIPTON,Sanjeev SATYAL,Hoyoung HUH
申请号：
US16648991
公开号：
US20200216463A1
申请日:
2018.09.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides novel cytotoxic compounds and cytotoxic conjugates comprising these cytotoxic compounds and cell-binding agents. More specifically, this invention relates to novel thailanstatin A analogs, useful as cytotoxic small molecule toxins in antibody-drug conjugates (ADCs). The present invention further relates to compositions including these cytotoxic compounds and ADCs, and methods for using these toxins and ADCs to treat pathological conditions including cancer.
