GERTRUDE P. CHAN, M.D., M.SC., FPDS,HEIDI P. CHAN, M.D., FPDS,MA. VENICE Y. CHAN, M.D.
申请号：
PH12014000281
公开号：
PH12014000281A1
申请日:
2014.10.08
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
Provided is an all natural microbial cellulose microparticle implantable dermal and subdermal filler derived from Nata de coco cellulose, wherein the microbial cellulose is fermented in coconut milk culture media, the active ingredient monolaurin is present in the amount of about 1 pcnt to 3 pcnt , the quality of the Nata de coco is higher than used as food in terms of cellulose content and appearance, and the size of the microbial cellulose is reduced to 300-900 nanometers after the final high pressure shearing. The final product passed the irritation, sensitization and the challenge tests, can be considered as non-irritating with low sensitization potential, and can be classified as hypoallergenic, biocompatible, biodegradable, non-toxic and non-immunogenic. Also provided are the process of producing the filler of the present invention, and the use of said filler for tissue augmentation, aesthetic correction of wrinkles or loss of facial volume and lipoatrophy correction.
